He has a reputation of being a committed and creative artist on both stage and screen internationally. Some of his work includes Simon from "Tengen Toppa Gurren Lagann", Sasuke Uchiha from Naruto, The Prince in Prince of Persia: The Sands of Time, Kamal Zaman from the alternate reality game I Love Bees, and Superman on Legion of Super Heroes. He also voiced teenage Ben Tennyson in the Ben 10 Franchise. Yuri often voices miscellaneous additional characters, and as such generally goes uncredited for his work. He also voices a familiar enemy in the horror series Bioshock, the Spider Splicer. The crazed voice of Sergio relates a lot to them.
Yuri Lowenthal and his wife, and fellow actor, Tara Platt co-authored the book, "Voice-Over Voice Actor: What It's Like Behind the Mic". They also started their own production company, Monkey Kingdom Productions, in 2004.
Lowenthal speaks fluent Japanese, French and German.