The terminals in the high school may change their location from test to test.
When splicing two creatures together, if you splice lobotomite and a dog together, they will always end up a failed experiment and both will be dead, when failing an experiment for the first time you complete a challenge that rewards 100XP.
Splicing together a robot and a night stalker will result in a robobrain that attacks a spot near the doorway with laser fire until it self destructs eight seconds later or is destroyed by the player.
It is also possible to splice together a lobotomite and a robot, creating a robobrain, the robobrain will self-destruct after a short time of talking.
Roxie, a temporary cyberdog companion, can be obtained by splicing a dog and robot together. Roxie will only follow the player around the X-8 Research Center. She can be used for the tests, but will not sneak with the player and runs toward any hostile in the area.
After 3 tests at the terminal, 24 in-game hours must pass in order for the system to "restock" test subjects.
On a wall in the high school area, "Why me, Mobius" is spelled out on the wall in large, physical letters.
One of the jars with a lump of brain inside from Point Lookout is on the desk near the entrance to the facility.
A terminal on level two mentions Project: Burke and Project: Hare. Burke and Hare were infamous 19th century serial killers who murdered people to sell their bodies as cadavers for anatomy classes. Project: Burke and Hare are both regarding procurement of bodies for scientific experimentation.
The created robobrain's short speech is a reference to the whale from The Hitchhiker’s Guide to the Galaxy by Douglas Adams.
In the high school area there will be a Wild Wasteland moment where you will see the phrase "Wolverines" written on the wall. This is a reference to the movie Red Dawn, as the Wolverines is a resistance group composed of high-schoolers, taken from the name of their football team, after their school (and America) is invaded by the Russians in the beginning of the movie.
In the cyberdog training area, you may find another Wild Wasteland Moment where you will look in a window to find a few cyberdogs playing Poker. It refers collectively to a series of sixteen oil paintings by C. M. Coolidge, commissioned in 1903 by Brown & Bigelow to advertise cigars. Known in Pop Culture as just Dogs Playing Poker paintings. In between the closest dog on the right and the left is an ace of clubs, just like in the painting.
xbox360 Splicing a Dog and a robot may create a goo pile under Roxie, the goo pile cant be searched unless Roxie is killed. Trying to search the goo pile while Roxie is alive will trigger her to talk to you.[verified]