Related to Janice and Jim Wilkins, Officer Wilkins is much less forgiving than Officer Taylor, and he blames you directly for the chaos currently affecting the vault. he is liable to attack as soon as he gives this "lone wanderer" a tongue-lashing.
When the Lone Wanderer returns to the vault in Trouble on the Homefront, Wilkins angrily talks about how much he despises the Lone Wanderer and his/her father, blaming the two for the dire situation Vault 101 is in after they escaped, saying "You never should have left, kid. And now we'll make sure that nobody ever leaves again!" This is most likely due to both of his kids being killed during the the vault riot.
If you go down to the basement sub-level during Trouble on the Homefront and enter the room where the Wanderer had to shoot the targets, where you encounter Officer Wilkins, you may find that opening the door and dropping a mine immediately would prevent officer Wilkins from entering his "you should have never left kid" dialogue, keeping him friendly. [platforms tag needed]
After opening the door, it is possible to see Wilkins spontaneously teleport back a good distance from the player character. [platforms tag needed]
ps3xbox360 Sometimes Wilkins will be in the path to the Overseer's office, and automatically turns the Overseer hostile, making it impossible to complete Trouble On the Homefront in certain ways.