Reception area with blocked stairs and an elevator to the right of the entrance. A few small rooms down a hall to the north with minor loot including a lunchbox. There is a collapsed floor in a kitchen leading up to the second floor.
Entry is on the north end with a pair of small offices. On the east side of the floor is a small theater room and Dr. Reid's office where one can see a bit of info about Vault-Tec's operations. On the south side is a bullpen-style office and stairs leading up.
On the east side is a conference room. The middle of the floor is a game room with a pool table. The north has a large office with a terminal and a safe.
The basement consists of a large warehouse areas with a locked terminal and back door.
- Mini nuke - In the toilet in the basement.
- Three Vault-Tec lunchboxes - One on the third floor on a desk in the back office, one on the first floor in the kitchenette and one on a shelf in the basement.
- Fusion core - On the roof of a building east of Vault-Tec Regional HQ. Can be accessed by climbing construction scaffolding and a fire escape (with one jump up from a skylight) on the building northwest of Vault-Tec Regional HQ's front entrance, then jumping down to the building northeast of the entrance.
- In the basement there is a skeleton wearing a lab coat stuffed behind some crates in the northeast corner of the room, most likely the remains of Sharon, as there is a pen next to the remains (mentioned in one of the terminals that Frank Davidson would stab her with a pen if she spilled coffee on him again), and it is mentioned she has been missing for a few days in a terminal entry nearby.
- On the third floor in the pool table room is a plastic pumpkin. Despite the fact that terminal entries indicate most of the former occupants of this office building seemed unaware of or shocked by the true nature of their employer, some rat poison can be found inside this pumpkin. It is—probably not coincidentally—located near the office of one Mr. Frank Davidson.
- Terminal notes talk about shipping 'jet' to Vault 95, which was invented between Fallout and Fallout 2, by one of the potential companions in 2, Myron.
The Vault-Tec Regional HQ only appears in Fallout 4.