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Vargas may refer to:
- Vargas, a member of Lyons' Pride in the Capital Wasteland chapter of the Brotherhood of Steel in Fallout 3.
- Manya Vargas, a resident of Megaton in Fallout 3.
- Nathaniel Vargas, Manya Vargas' husband and resident of Megaton in Fallout 3.
- Manny Vargas, former Great Khan and ex-1st Recon sniper living in Novac, in Fallout: New Vegas.
- El Diablo, born Miguel Vargas, a "vampire" from Denver in Van Buren.
- Real-life person: