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Vargas may refer to:
- Vargas (Brotherhood of Steel), a Brotherhood of Steel Paladin in Lyons' Pride, in Fallout 3.
- Manya Vargas, a resident of Megaton in Fallout 3.
- Nathaniel Vargas, Manya's husband and resident of Megaton in Fallout 3.
- Manny Vargas, former Great Khan and ex-1st Recon sniper in Novac, in Fallout: New Vegas.
- El Diablo, born Miguel Vargas, a "vampire" from Denver in Van Buren.
- Real-life person: