New information (many spoilers!):
- Vault 21 is an underground vault and lies under New Vegas.
- The NCR has lost contact to the west and is demoralized and underequipped due to the war with Caesar's Legion.
- Caesar's Legion dominates New Vegas.
- The NCR was fighting hard against the Brotherhood of Steel for Hoover Dam. The NCR has won this battle, barely.
- The NCR troops at McCarran Airport lost the contact to Hoover Dam as well.
- The main task of the courier has been to deliver a package to Primm. Then he got ambushed...
- The small and big weapons skills are merged into one weapon skill.
- Every weapon that made some asplozions before (like the rocket launcher or Fat Man), are now in the skill category Explosives.
- REPCONN test site, a former rocket factory, is supposedly inhabited by ghouls. As of late, explosions can be heard from there all the time.
- Craig Boone, one of the possible companions, will attack the player, if he sides with the Caesar's Legion.
- The orbital laser Archimedes II can only be used once a day.
- New monster: Cazadores, they look like bloatflies with shiny / colourful wings.
- Something like Bobbleheads will be in New Vegas as well and it will boost players stats. What it will be exactly isn't known yet.