The Regulators are a group of vigilantes who wear cowboy style hats and Regulator dusters after the fashion of gunslingers. In the Capital Wasteland they are led by Sonora Cruz and operate out of a farmhouse. Unlike the corrupt Regulators seen in the original Fallout, the (non-related) Regulators of the Capital Wasteland are truly just-minded and seek to punish evil.

If the player has the Lawbringer perk, he/she can trade fingers taken from the corpses of evil humans or (non-feral) ghouls killed by the player, for good karma and bottlecaps. The Regulators will also attempt to claim the bounty on the player's head if he or she has bad karma by committing serious crimes, such as destroying Megaton or enslaving people in the Capital Wasteland.