1) Perform the Shady Sands Shuffle on Herbert Dashwood.
2) Draw the Mysterious Magnum while wearing a Duster and Fedora.
3) Fight a Deathclaw with a Deathclaw Gauntlet.
4) Kill the NCR President in the quest, Arizona Killer, with the Euclid's C-Finder.
5) Shoot a Radscorpion with a Dart Gun, which ironically is poisoned with Radscorpion Poison.