On Kotaku, he said that even though ZeniMax acquired id Software and its id Tech 5 engine, they are going to stick with their version of the GameBryo engine for their next big game they're making since they finished Fallout 3, updated and retooled to some extent. The thing they intend to improve the most in the engine is their animation system and graphics in general.
Howard also said that while Bethesda Softworks as such might publish some third-party projects for the Wii, there are no plans for any of the Bethesda Game Studios franchises (Elder Scrolls, Fallout) to appear on Nintendo's platform. However, they have been talking about bringing their games to the Mac, especially now that they have id, who have always been supporting Macs, on board.
You can listen to the whole podcast here.
On NPR, Howard talks about working in the gaming industry in general:
It's a reality for many people in the video game industry, including Todd Howard. At midday on a recent Friday, he was playing Fallout 3 in his office. When Howard, 39, first started at Bethesda Softworks in Rockville, Md., 15 years ago, his parents told him to have a backup plan.He didn't need one.”