We are also pleased to say that we have just released a second fix for PC users to address the autosave and quicksave issues that some people were encountering. That particular issue was never seen prior to release and it was extremely difficult to reproduce reliably, even after the game had launched. In order to fix this problem we have had to disable Steam Cloud functionality. It has been turned off, and we won't turn it back on until we're absolutely sure it will not cause any more problems. Please restart your Steam client to make sure you get the update.
(...)On consoles, we are aware that a small group of 360 users are seeing a DLC warning which is preventing you from loading save games. We are absolutely looking into this bug now, along with other reports of save game corruption. It is our highest priority right now that we find out what is causing it. In the meantime, we recommend you save often, and revert to an older save if this occurs.”
Bethesda is also working with certain hardware manufacturers to improve the performance of the game for certain video cards, and continues to work on general memory and stability issues.
He also mentioned a few things that are not actually bugs, even though they have been reported as such:
We have seen forum posts where people are claiming they are not getting all of their perks. Again, this is not a bug. In Fallout: New Vegas, you receive perks every other level, not every level as you do in Fallout 3.And finally, a quick tip: Be aware of your faction status before assuming the game is broken. Factions will react very strongly to you based on your current armor. If you’re wearing Powder Ganger or Caesar’s Legion armor, you will be shot on sight by the NCR (and vice versa). Also note that there are groups of renegade Powder Gangers (known simply as “Escaped Convicts”) who will shoot you regardless of your faction status.”