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Tyrone may refer to:
- Tyrone, a member of a small commune based in the Hilltop Farm ruins mentioned in Fallout 3.
- Tyrone, an NCR soldier in Primm in Fallout: New Vegas.
- Tyrone Cutchin, an NCR trooper who fought, and died, during the First Battle of Hoover Dam, mentioned in Fallout: New Vegas.