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The Nuclear Option may refer to:
- The Nuclear Option (Brotherhood of Steel) - main quest in Fallout 4, given by Elder Maxson, leader of the Brotherhood of Steel
- The Nuclear Option (Minutemen) - main quest in Fallout 4, given by Preston Garvey, second-in-command of the Commonwealth Minutemen
- The Nuclear Option (Railroad) - main quest in Fallout 4, given by Desdemona, leader of the Railroad