Set is the leader of all the ghouls in Necropolis in 2161, except for the underground ghouls who lived in the sewers and the glowing ones who live in Vault 12. He has a son called Typhon. Set is annoyed at the super mutant presence in Necropolis and tries to recruit the Vault Dweller to take care of the problem. He is not mentioned in the Vault Dweller's memoirs, but the Vault Dweller did kill the super mutants, which led to the slaughter of everyone in Necropolis, including Set himself.