Susan can be found in a different bed every night of the week between 10PM and midnight, always wearing sexy sleepwear. On Monday, she's in Wellington's bed, the Doctor has her both Tuesday and Thursday night, she's with Hawthorne on Wednesday, Mr. Cheng on Friday, and Sunday nights are spent with Dashwood. Even after moving in with Mister Burke, she continues her weekly rounds, and never gets around to sharing a bed with him. She has an affair with every man in Tenpenny Tower, except Anthony Ling, who is implied to be a homosexual.
Strictly Business: Susan is one of the VIP's Grouse wants you to bring in. If you have completed the Tenpenny Tower quest in the ghouls' favor, Susan will be counted as dead when you acquire the Strictly Business quest.
Tenpenny Tower: Susan is one of the residents you have to convince to allow the ghouls to live in the tower.