There is a handful of raiders guarding the school's entrance. The school's interior is completely free of enemies. The high school is very small, the downstairs containing a bathroom with a first aid box in it. Upstairs is a room with a chemistry station and an advanced safe.
- 3 Vault-Tec lunchboxes: The first is in an open locker in the northwest corner of the first floor. The second is on the floor in front of a locker outside the men's restroom on the south side of the 1st floor. The third is buried in the pile of mud on the left hand side of the entrance.
In a locked closet, one can find the dismembered limbs and torso of a marble statue. The statue pedestal is in the graveyard of the South Boston Church, located a few blocks east of the school.
South Boston High School only appears in Fallout 4.