There is a handful of raiders guarding the school's entrance. The school's interior is completely free of enemies. The high school is very small, the downstairs containing a bathroom with a first aid box in it. Upstairs is a room with a chemistry station and an advanced safe.
- 3 Vault-Tec lunchboxes: The first is in an open locker in the northwest corner of the first floor. The second is on the floor in front of a locker outside the men's restroom on the south side of the 1st floor. The third is on the pile of mud on the right side of the entrance.
In a locked closet, one can find the dismembered limbs and torso of a marble statue. The statue pedestal is in the graveyard of the South Boston Church, located a few blocks east of the school.
South Boston High School only appears in Fallout 4.