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There are a handful of raiders guarding the school's entrance. The school's interior is free of enemies. The high school is very small, the downstairs has a bathroom with a first aid box in it. Upstairs is a room with a chemistry station and an advanced safe.
- 3 Vault-Tec lunchboxes: The first is in an open locker in the Northwest corner of the first floor. The second is on the floor in front of a locker outside the men's restroom on the South side of the 1st floor. The third is on the pile of mud on the right side of the entrance.
In a locked closet, you can find the dismembered limbs and torso of a marble statue. The statue pedestal is in the graveyard of an unmarked church a few blocks east of the school. In the graveyard you can find a hatch to the church basement, which includes a few ghouls, a cat, a shrine to the cat and an ammo box with random contents.
South Boston High School only appears in Fallout 4.
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