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As with all houses in Tranquility Lane, it has 2 stories with the front door entering into the lounge. On the ground level, there is also a bathroom and a kitchen. Upstairs, the house has another bathroom, a study and a bedroom containing lacy underwear with a queen sized bed.
- The Simpson residence contains one special item that can be interacted with to complete Betty's tasks, namely the lacy underwear.
- As with all houses in Tranquility Lane, the Simpson residence looks untouched by the war.
Simpson residence appears only in Fallout 3.