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Seth may refer to:
- Set, the leader of all the ghouls in Necropolis in 2161 in Fallout.
- Seth (Fallout), the leader of the guards of Shady Sands in 2161 in Fallout.
- Seth (Fallout 3), a worker for Nuka-Cola Corporation R&D at the Nuka-Cola plant mentioned in Fallout 3.
- Seth (Fallout 4), a member of an unknown group in the Commonwealth in 2287 mentioned in Fallout 4.