Seneca Clarkson was a pre-War prostitute who worked at the Statesman Hotel in Washington, D.C.. She was found dead in room 302 of the hotel, suffocated with a plastic bag over her head, and being tied to the bed posts, with the man present at the time claiming it had: "Just been a bit of fun."

In another incident involving Ms. Clarkson, Tom Mallone had to be treated at Our Lady of Hope Hospital after having suffered a severe groin pull caused by her.

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Seneca Clarkson is mentioned in two terminal entries in Fallout 3, but does not actually appear in the game.