Second Street contains the following locations:
- Golden Globes (owned by the Corsican Brothers)
- Jungle Gym (owned by Stuart Little)
- Salvatore's Bar (owned by Louis Salvatore)
- Shark Club (owned by John Bishop)
Second Street connects to Virgin Street to the south.
- Become a Porn Star - The Corsican Brothers are looking for a porn star, but the Salvatores are looking for the Brothers because of the late payment.
- Become a Prizefighter - Jungle Gym has a lot of fights each night... and it is looking for any fighter for the ring.
- Louis Salvatore needs a man (or woman) to do a job, though people will find it hard getting through Mason first.
Second Street appears only in Fallout 2.