Sandra is one of the few Pitt raiders with a solid education, and she deliberately approached the Pitt because she saw it as a strong up-and-coming force in the wasteland. Ashur recognized her intelligence immediately and offered to support her work. Sandra's friendly demeanor hides a fierce intelligence and absolute conviction. Sandra has no illusions about the cutthroat nature of the Pitt's raiders. In fact, she shares a good deal of their ruthlessness, although she prefers to avoid direct violence, if possible. She wholeheartedly supports Ashur's plans to build an army and unite the wasteland.
If you take Marie, Sandra will threaten you, but may not immediately turn hostile.
If you side with Wernher, she will be waiting alongside Ashur in the Haven courtyard to fight you.
She is polite and well spoken at first, however if Marie is taken she will become extremely hostile and hurl a variety of creative threats and violent insults at you, e.g. "I'll cut off your fingers and give them to Marie as pacifiers" or, I'll string you up and keep you alive until Marie is old enough to shoot at you herself!"
If you have general subtitles on when walking into her lab area, quotes like "Well if it isn't the smartest asshole in The Pitt" will come up. There are no vocals but she is the only one there aside from Marie.
If you kill Sandra but do not take away Marie, the game will still treat you as if you have sided with the Raiders. This does not affect Ashur and he will still suggest talking to his wife about finding toys.