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Sandra may refer to:
- Sandra Abbot, an NCR private who fought and died during the First Battle of Hoover Dam who is mentioned in Fallout: New Vegas.
- Sandra Kundanika, a Pitt raider scientist in The Pitt in Fallout 3.
- Sandra Lee, a resident of Far Harbor in the Fallout 4 add-on Far Harbor.
- Sandra (Fallout 4), a mentioned-only character student who attended University Point before the Great War in Fallout 4.