This entire group showed up throughout the course of the day displaying the same symptoms. They're remarkably similar to Dr. Peters' condition when he first came a week ago. I hope we don't have a contagion on our hands.”— Vault 22 terminal entries - Case 164 (group)
Samwise Horton was a Vault resident during the experiments inside Vault 22.
Samwise Horton was one of the first infected by the spores from one of Vault 22's experiments.
Samwise Horton is mentioned only in Fallout: New Vegas.