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Samuel may refer to:
- Sammael, a scavenger in Adytum in Fallout.
- Samuel (Fallout 3), a feral glowing ghoul in Fallout 3.
- Samuel Johnson, a man who worked at L.O.B. Enterprises before the Great War, mentioned in Fallout 3.
- Samuel Cooke, an anti-NCR revolutionary and a Powder Ganger in Fallout: New Vegas.
- Samuel Kerr, a trader running the 188 trading post with his daughter Michelle Kerr in Fallout: New Vegas.
- Samuel (Fallout 4), the grandson of Phyllis Daily, mentioned in Fallout 4.
- Samuel T., a kid who resided in Vault 75, mentioned in Fallout 4.
- Samuel Martin, a record-holder bowler at the Beaver Creek Lanes, mentioned in the Fallout 4 add-on Far Harbor.
- Real-life people: