In sharp contrast to his name, James is anything but a saint. He is a scavenger and prospector turned slaver, and he sells refugees, mostly young women, as slaves for the Fiends. He verbally abuses the Courier, telling them to "fuck off" whenever the Courier exits conversation with him. Also, it is revealed he has sex with Sweetie, and recently, he has been putting a teddy bear near him on a table as he engages in sex with her. Sweetie describes this as "creepy and perverted but not the worst she's dealt with."
While searching his room for the quest The Coyotes, if you take his teddy bear from his room and keep it, this will unlock a dialogue option with James regarding the teddy bear, which according to Captain Parker, belonged to a little girl that went missing from Aerotech Office Park.
pcps3xbox360 At around 12:00 midnight, James will try to go inside to his apartment room. However, he does not have a key and can not get in (unless the player has picked the lock on the door). He will walk back and forth outside his apartment room until he is scripted to go back outside. This prevents the player from being able to slip into his room behind him to search for clues during The Coyotes quest. [verified]
ps3xbox360 After being given the quest, St. James never shows up at Casa Madrid. The map marker points to an unreachable location, sometimes near the Lucky 38. Impossible to complete if this happens. Some players can't find him even before the quest is given, even through waiting. This means the quest can't be begun or completed. [verified]
ps3xbox360 Occasionally, after killing St. James, his corpse will still show on the map as a quest marker. [verified]