Paulie is your classic addict. His wife, Cindy, runs A Quick Fix, which sells chems. The shop would actually make money if he would stop using up all the inventory himself. Most of his waking thoughts are about when he can get his next fix. He is frequently distracted and has trouble focusing. Paulie and Cindy are married in name only. They barely talk and share little in common. He isn't even aware of how much he neglects his wife.
If you have Psycho in your inventory, you can give it to him for negative Karma (-100 points). If you want additional negative Karma, you should give him as much psycho as you can before he dies. There are actually some drugs (including psycho) on his own desk. You can steal them and give them back to him.
He can be mezzed, enslaved, and sent off to Paradise Falls. No dialogue change with his wife, however.