Nothin' But a Hound Dog: You may approach Old Lady Gibson about using Rey's brain in Rex. She will ask for 700 caps for this "favor" as he's like one of her family. She says he's getting old and he would probably need to be put down soon anyways. It's free with a Barter check (70). After you kill him, you can use his brain for Rex. Using Rey's brain on Rex will increase Rex's ferocity in battle.
ED-E My Love: Talking to Gibson will activate ED-E's first audio log.
She carries the unique sawed-off shotgun, Big Boomer.
To the west of her place you can find a mountain line, search north of that and you will eventually find a shack with no marker called Gibson's Shack. This shack is part of I Could Make You Care.
She tends to have a high number of caps available (initially 2000; 12,000 or more late in the game) making her a good place to walk to if over-encumbered nearby (such as after completing "We Are Legion") or just looking to sell junk.
pcxbox360 She has a pair of duplicate casino edition caravan cards, if you buy both the game will crash but if you only buy one the game will continue and the extra card will disappear from her inventory. [verified]
pcps3xbox360 It appears that if you come to Gibson Scrap Yard and talk to Old Lady Gibson before obtaining ED-E, she will not give you the unique dialogue options required to continue the quest, and ED-E merely ignores her. Use setstage 001572E8 10 console command to reset the dialogues and continue the quest. [verified]
pcxbox360 Old Lady Gibson may stop giving you caps for any items that you sell to her. The items will disappear from your inventory, but no caps will appear in their place. The items will not appear in her sell screen or inventory, either. [verified]
xbox360 If your quest marker leads you to Helios One Solar Array area it may point you to the ground meaning that you may have killed Old Lady Gibson. The only way to finish the quest is to return to her garage and obtain the thrust control components from one of the containers. Note that the quest marker will be stuck in place and will not show you back to the garage. Simply ignore it, get the components from her garage, and the quest will update from there. [verified]
xbox360 At some point later in the game fast traveling to Gibson Scrap Yard may cause there to be a Legionary Assassin sitting outside in Old Lady Gibson's seat. She will still come out in the morning but will stand near the door. If you fast travel away and back again you will find Old Lady Gibson is now seated and the assassin is now standing beside her. When she goes to bed at night he will sit again. It is unknown if he will ever leave. [verified]
xbox360 Occasionally, when she is inside eating, Old Lady Gibson will become invisible, but still able to interact with the player. [verified]
xbox360 Occasionally when leaving Helios One through the room near Fantastic, you will find Old Lady Gibson and her dogs accompanied by several mole rats, all hostile. Loading the auto save will get rid of her however. Also if you walk around a bit you'll bump into invisible items that came from the Gibson Scrap Yard. [verified]
ps3 Before any patches when you ask Old Lady Gibson to repair an item the console will crash and freeze. [verified]
ps3 Occasionally when Old Lady Gibson is killed while sleeping her body will appear on the opposite side of the room. [verified]
xbox360 When you talk to her with ED-E, and she activates his Enclave data, she will be gone the next time you come to see her. She could just pop up after that at HELIOS 1 but it is not for sure. This can be very annoying because you will not be able to buy or sell anything to her ever again. [verified]
ps3 Sometimes when trying to sell an item to Gibson, your item will be removed from your inventory, but you will not receive the caps. This can cost players lots of money if they don't make sure the caps are being received. [verified]
pc If you kill her and steal the key, then take her items from her safe, she will shout "Don't take that!". [verified]
ps3 Old Lady Gibson can appear walking in mid air and then land on the ground between Helios One and Camp Forlorn Hope. [verified]
pc When using the repair option when talking to her it is possible for the game to freeze. [verified]
xbox360pc Occasionally after you kill Old Lady Gibson she will not have the Big Boomer in her inventory. [verified]
pc If she is attacked when near the player and companions by a hostile NPC, such as a raider, she and her dogs may inexplicably turn hostile to the player and companions. [verification needed]