She debuted at an early age, playing a young student in Kindergarten Cop and later moved on to various television shows and movies such as South Beach and October Road. In 2007, she starred in the Lifetime original movie Reckless Behavior: Caught on Tape and followed it quickly with a lead role in J. J. Abrams' Cloverfield. Also, in 2009, Yustman starred in the horror flick, The Unborn. In 2011, Yustman co-starred in the television shows, House, and Breaking In.
Fallout 3 is the first voice acting job in Yustman's career.