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Nuka-grenade may refer to:
- Nuka-grenade (Fallout 3), a plasma grenade variant in Fallout 3.
- Nuka-grenade (Mad Bomber) (GRA), a plasma grenade variant in the Fallout: New Vegas add-on Gun Runners' Arsenal.
- Nuka grenade (Fallout 4), a plasma grenade variant in Fallout 4
For crafting schematics, see Schematics - Nuka grenade.