Nuka-Cola was invented in 2044 by John-Caleb Bradberton. Its unique taste gained widespread popularity, quickly becoming the most popular soft drink in the United States with an extremely dedicated following. The widely known dazzling blue bottle color was adopted as standard in 2052, after market research programs indicated that the blue color was the favorite in 86 people out of 100 polled.
The ingredients of Nuka-Cola include: carbonated water, caramel color, aspartame, phosphoric acid, potassium benzoate (to protect taste), natural flavors, citric acid, and caffeine. What gives it a unique flavor is the essence of seventeen different fruits mixed in just the right proportion to give the beverage its trademark taste. Some versions of the drink also include vita-minerals and health tonics. During the Great Passion Fruit Famine of 2044, people actually noticed the taste difference when the recipe was changed.
Nuka-Cola was the most popular flavored soft drink in the United States before the Great War. After the War, Nuka-Cola remains one of the most popular soft drinks of the post-nuclear world, as much of it was preserved in a fairly pristine state, although it tends to be warm, irradiated, and flat. In Fallout 4, Nuka-Cola bottles take on a newer look.
Nuka-Cola machines, other than for reasons of gameplay, restock every one to seven weeks. In Fallout Tactics, there is a special encounter with a man pedalling a bicycle cart. This is Phil, the Nuka-Cola dude, who claims via bubble text to be personally responsible for restocking the vending machines of the wasteland. An unlimited quantity of Nuka-Cola can be purchased in the Broken Hills bar (this may be explained indirectly by the Homebrewed Nuka-Cola recipe in Fallout: New Vegas).