From the outside it looks similar to a normal Nipton residence, but as the door name suggests, it is a hotel. It is speculated that the Nipton Hotel is an office building, as the interior is small with multiple seats, filing cabinets, and a reception desk with a cash register. The trailers to the south of Nipton may have been rentable from this building.
It is set to the west of Nipton Hall.
The building is noticeably smaller than the actual cell inside.
Nipton Hotel appears only in Fallout: New Vegas.