From the outside it looks similar to a normal Nipton residence, but as the door name suggests, it is a hotel. It is speculated that the Nipton Hotel is an office building, as the interior is small with multiple seats, filing cabinets, and a reception desk with a cash register.
It is set to the west of Nipton Hall.
The building is noticeably smaller than the actual cell inside.
Nipton Hotel appears only in Fallout: New Vegas.