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From the outside it looks similar to a normal Nipton residence, but as the door name suggests, it is a hotel. It is speculated that the Nipton Hotel is an office building, as the interior is small with multiple seats, filing cabinets, and a reception desk with a cash register.
It is set to the west of Nipton Hall. There is only one small, main area in the building. On the floor, there are 4 dead NCR troopers, each wearing a different kind of NCR armor, and carrying NCR dogtags.
The building is noticeably smaller than the actual cell inside.
Nipton Hotel appears only in Fallout: New Vegas.