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Murphy may refer to:
- Murphy, a chemist and drug dealer responsible for Ultrajet in Fallout 3.
- Mama Murphy, a drug addict and settler in Sanctuary Hills in Fallout 4.
- Mayor Murphy, a fictional character in the Silver Shroud Radio in Fallout 4.
- "Beans" Murphy, a salvager at Denver in Van Buren.
- J. Hardy Murphy, an adventurer from The Armageddon Rag.