The women of New Vegas ask me a lot if there's a Mrs. New Vegas. Well, of course there is. You're her. And you're still as perfect as the day we met.
Mr. New Vegas is an AI programmed by Mr. House, before the Great War, to be the DJ of Radio New Vegas, a job he still performs over two hundred years later in 2281. He is heard in-game on the radio, but never actually seen.
He makes comments and gives advice on the Courier's active quests, such as revealing what the Courier must do or is going to do. Much like Fallout 3's Three Dog, Mr. New Vegas also reveals some future details of the ending of Fallout: New Vegas, including the possible takeover of the NCR, Caesar's Legion and Mr. House.
Mr. New Vegas rarely mentions the Courier specifically, possibly because of lack of information (except when the Courier leaves Doc Mitchell's house). This is in contrast to Three Dog who knows the Lone Wanderer, describing him/her as "the kid from Vault 101".
Mr. New Vegas is voiced by real-life Vegas-based star Wayne Newton, also known as "Mr. Las Vegas".
Mr. New Vegas' line, "Mojave, mo' problems. Am I right folks?" is a reference to the rapper Notorious B.I.G.'s song "Mo' Money, Mo' problems." This line is only heard if the player takes the Wild Wastelandtrait.