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Melissa may refer to:
- Melissa Lewis, a Great Khan living in the Mojave Wasteland in Fallout: New Vegas.
- Melissa Watkins, an initiate of the Brotherhood of Steel in the Hidden Valley bunker in Fallout: New Vegas.
- Melissa Bai, a soldier who fought, and died, during the First Battle of Hoover Dam, mentioned in Fallout: New Vegas.
- Real-life people: