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Mel may refer to:
- Mel (Fallout 2), the defender of Dogmeat should the Chosen One hurt him in Fallout 2.
- Mel (Fallout 3), an ineffective mugger the Lone Wanderer may come across in a random encounter in Fallout 3.
- Mel (Fallout 4), a recruitable tech expert and owner of Sonya. He can be interacted with during the quest The Big Dig.