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Mechanist may refer to:
- Mechanist (Fallout 3), a male character and aspiring costumed hero in Fallout 3.
- Mechanist (Fallout 4), a fictional character and central antagonist in the Silver Shroud Radio show in Fallout 4.
- Mechanist (Automatron), a female character and the central antagonist in the Fallout 4 add-on Automatron.