Manya was born in 2213. At age 64, she is a sweet old lady. She and Nathan used to run a caravan line together and have managed to save enough caps and supplies to live out their retirement in Megaton. Manya's sweet exterior doesn't reveal that she's witnessed every misery that the wasteland has to offer. She is extremely wise and knowledgeable - two traits that allow her to continue to thrive and live in Megaton.
There is a unique dialogue choice regarding Megaton's ownership if Sheriff Simms dies.
Manya is one of the oldest residents of Megaton, and thus knows much about the history of the town. If you ask her about Megaton and how it was built, she will tell you stories about how the town started.
Occasionally Manya is asking if you have seen her husband, Nathan. However if, you find him and even talk to him, she will still ask if you have seen him. Nathan also wonders about where Manya is at random times.
If Nathan is killed at Raven Rock during The American Dream, or at all, the player will no longer be able to open dialogue with Manya, instead she will simply acknowledge that he is dead, and will sometimes drift off thinking of him before he died, indicating she cared for him far more than previously indicated, saying, "Sorry, I was just thinking of Nathan before he died," if the player tries communicating with her. Oddly, if she communicates with you, she will simply ask, "Have you seen Nathan anywhere?"