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Mack may refer to:
- Allen Mack, a resident and possible Overseer of Vault 101 in Fallout 3.
- Gloria Mack, wife of Allen Mack and mother of Susie, Wally and Stevie Mack in Vault 101 in Fallout 3.
- Stevie Mack, a member of Vault 101 security in Fallout 3.
- Wally Mack, a member of the Tunnel Snakes and son of Allen and Gloria Mack in Vault 101 in Fallout 3.
- Susie Mack, daughter of Allen and Gloria Mack and resident of Vault 101 in Fallout 3.
- Mack (Mister Handy), a robot found at General Atomics Galleria in Fallout 4.