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Luke may refer to:
- Luke (Fallout), an informative citizen of the Hub in Fallout.
- Luke (Fallout 2), a member of the Brotherhood of Steel at the NCR Brotherhood outpost in Fallout 2.
- "Blind" Luke, a man found dead in the central sewers in Fallout: New Vegas.
- Luke Daniels, a raider leader in Fallout Tactics.
- Luke Silverhand, a treasure hunter found dead in Jamaica Plain in Fallout 4.
- Real-life people: