An elderly, well-dressed gentleman, Salvatore's face is gaunt and covered with liver spots. Due to his age, he has trouble breathing and must rely on a steady supply of oxygen to control his respiratory problems, always wearing a breathing mask, connected to an oxygen tank by his side. This old man is a gangster from long ago and is the oldest mob patriarch in New Reno. His family has clung to their waning power for generations, growing envious of the Mordinos' power. After establishing a profitable drug and slave enterprise with the Enclave, he ordered his men to massacre Mordino men in the street with newly-acquired energy weapons, their twitching bodies signifying his return to the game.
His right-hand man and personal bodyguard is Mason, to whom he relegates the specifics of jobs for those under his employment. He is personally responsible for having Renesco poison the dose of jet that caused Richard Wright's death, in the hope of provoking a war between the Wright and Mordino crime families.
In order to help guard Enclave transaction, it is important to be nice to Mason and Mr. Salvatore himself (attempting to dialogues only with Charisma 6 and above, always choosing "Yes, Mr. Salvatore"-like options with IN > 8). In this case, after completing prior quest, Salvatore will pay a 25% cut off from the delivered money and give the quest.
Mr. Salvatore has additional scripting that makes him suspectible to a single super stimpak.
He is most likely inspired by a similarly-named character from the animated film Batman: Mask of the Phantasm. Not only do they share similar names but their appearances are similar, they are both quite elderly, and both need to keep an oxygen tank and mask at hand at all times.