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Lou may refer to:
- The Lieutenant, also known as Lou or Lou Tenant, the Master's right hand super mutant, High Commander of the Master's Army and overseer of the Mariposa Military Base in Fallout.
- Louise, the owner of Malamute Saloon in Redding, who is often called Lou, in Fallout 2.
- Cindy-Lou Kreb, an employee in the human resources department for the H&H Tool Company, mentioned in Fallout: New Vegas.