Leslie is a well-educated and well-mannered woman, who was originally a Vault City Citizen, but left when she fell in love with John (though that might've been the drugs he offered her). Their relationship was not a happy one, despite the fact that she gave him a daughter, Angela. Over the years, she grew to hate her husband along with New Reno. Seeking refuge in alcohol, drugs and the occasional sexual endeavor, she longs for a different way of life.
Eliminate Mr. Bishop: Mrs. Bishop can tell the combination to Bishop's safe, allowing the Chosen One to change it. They can rig it with an explosive, making Mr. Bishop detonate it when he tries entering his combination.
If the Chosen One is strong or attractive enough, when spoken to, Mrs. Bishop will ask them to accompany her to her chambers for a drink. Of course, this little meeting ends in bed. If the Chosen One does not have a condom in the inventory, he will impregnate Mrs. Bishop and trigger an ending for New Reno, where his son takes over the family and rules it until he dies in the age of seventy-three (2315), never knowing his real father.
It should be noted that this is most likely canon, as in Fallout: New Vegas the singer Bruce Isaac states that he is being hunted by a "Mister" Bishop from New Reno, meaning that the Chosen One did most likely impregnate Mrs. Bishop. However, if the Chosen One kills John Bishop sometime after and later convinces Leslie Anne to move on, his son would return with an army of tribals, taking over the city.
Regardless of sex, if the Chosen One performs, Mrs. Bishop will fall asleep contentedly and mutter the combination to her safe.
If the Chosen One has the Kama Sutra Master perk, Mrs. Bishop will have all dialogue options available.
In combat, Mrs. Bishop is named "Lee Ann Bishop" in the message window.
When rejected and after accepting her drink, the Chosen One can respond to her shouting for the guards with "Fuck! I hate this game!". This can be interpreted as either fourth wall breaking or the player character responding to Leslie Anne's anger.