Leslie is a middle-aged, well-educated, attractive woman, who was originally a Vault City Citizen, but left when she fell in love with John (though that might've been the drugs he offered her). Their relationship was not a happy one, despite the fact that she gave him a daughter, Angela. Over the years, she grew to hate her husband along with New Reno. Seeking refuge in alcohol, drugs and the occasional sexual endeavor, she longs for a different way of life.
Eliminate Mr. Bishop: Mrs. Bishop can tell the combination to Bishop's safe, allowing the Chosen One to change it. They can rig it with an explosive, making Mr. Bishop detonate it when he tries entering his combination.
If the Chosen One is strong or attractive enough (ST 6 or CH 6), upon ending the conversation, Mrs. Bishop will ask them to accompany her to her chambers for a drink. Of course, this little meeting ends in bed (unlike her daughter, she doesn't have anything against women, either).
If the Chosen One does not have a condom in the inventory, they will impregnate her and trigger one of two endings for New Reno where she bears a son. This has been observed in games whether the Chosen One is male or female. [verification overdue]
Normally, denying Mrs. Bishop would incite the guards; however, if the Chosen one has a high enough charisma stat, they can convince her that they, "...have a special transaction with Jules," and may leave with no consequences.
In combat, Mrs. Bishop is named "Lee Ann Bishop" in the message window.
When rejected and after accepting her drink, the Chosen One can respond to her shouting for the guards with "Fuck! I hate this game!". It can be interpreted as either fourth wall breaking or the player character being upset about Leslie Anne's anger.