Unlike his peers, Lawrence Higgs has a low opinion on the Institute's dependency on synths with his belief that humanity will grow stagnant if they rely too much on synths. When the Sole Survivor first meets Lawrence, he is seen having a frustrating conversation with a synth before talking to the Sole Survivor in which he expressed his discontentment with synths.
When learning Father appointed the Sole Survivor as his successor, Lawrence protested the Sole Survivor's promotion by locking himself and Dr. Loken in the Institute Bioscience Laboratory. Newton Oberly tried to reason with Lawrence and Loken, but to no avail. The Sole Survivor is forced to either talk down the rebel scientists or kill them.