Once the Vault Dweller has given Neal's urn to Vinnie, he will ask for the Dweller's help with killing Neal. If the action is accepted, he will be transported to the Skum Pitt. Once Neal and Trish are dead, the Vault Dweller receives 300 XP and negative reputation.
After the rendezvous with Vinnie at the bar, it is possible for the Vault Dweller to end "turn" throughout the combat sequence without being targeted; Companions will not interfere but instead move and not attack unless accidentally misfired at. The player can choose to end combat after the outcome which almost always ends in Vinnie being killed. After returning to the Skulz hideout the player will be confronted with a respawned Vinnie who will accordingly say "Soon, Neal gets his, huh?" when interacted with. Oddly enough, revisiting the Junktown Casino section renders the camera to fixate on the bar with the dialogue and quest practically resetting without the player's presence in the ordeal.
Even in the case that the PC and/or Vinnie kills Neal and Trish, the Skulz can become hostile upon return to their base, a bug possibly stemming from Champion karma or the completion of the Stop Gizmo quest.