Keats is a super mutant who is highly intellectual and has given up on the whole taking over the world thing, replacing it with hopes that humans and mutants can live together peacefully. He is the current leader of Austin, however, his plans are hindered by an infestation of mutant plants and the loss of power to the city.
If the player character has a good reputation Keats will ask them to deal with the mutant plant infestation so that the power can be restored, he would do it himself but he wants to show the mutants that humans can be trusted. The player character will have found a G.E.C.K. and a strange data chip during this quest and leaves them with Keats and his scientists to study while he tasks the player character with defending the Brotherhood of Steel base of operations in Alamo from an attack by the Twisted Hairs who are marching upon them. When the player character returns from the Alamo Keats will invite them to a speech he will make to the inhabitants of Austin.
If the player character sided with Shale when first entering Austin, he will task them with assassinating Keats during his speech.