Bishop is a powerful man, controlling one of the two most powerful families in the city (the Mordinos are arguably just as influential, since they corner the Jet market). He is seeking to end New Reno's mob-based anarchy by bringing it into an alliance with the NCR and Vault City. As part of this process he is working within the NCR's congressional system to legalize prostitution and gambling within the Republic. The NCR hired Bishop as a middleman, who in turn hired the raiders who harass Vault City, in the hopes that Vault City will turn to the NCR for protection.
He is a neglectful husband, indifferent to the fidelity of his wife Leslie Anne Bishop, and he cheats whenever it suits him. He has also provided little guidance for his daughter, Angela Bishop, who like her mother is promiscuous and also a Jet addict. Nevertheless, he is extremely possessive and easily incited when one impinges on his perceived territory. Bishop once skinned a boy whom he found out had gotten his daughter drunk.
If the Chosen One has sex with Angela Bishop and/or Mrs. Bishop, if they speak to Mr. Bishop and refuse to take a quest for him, he will threaten them to do the job or pay for their actions. Continued refusal, or visiting him again without completing the quest, will turn him hostile.
Bishop can be killed discreetly by changing the combination to his safe, thereby killing him with his own booby-trap. To do this, one has to sleep with Mrs. Bishop, and afterwards suggest killing her husband by way of an "accident" (this option only appears if the Trap skill is at 76%). Then go to Bishop's safe and "repair" it to change the combination. Then leave and return later to find Bishop dead. If the Chosen One sets off the trap on Bishop's safe himself, he will have to "use" plastic explosives or TNT on it to re-arm the trap before "repairing" it to change the combination.
It is possible to escape John Bishop after sleeping with either or both Bishop women (Mrs. Bishop and Angela Bishop). The player's Sneak skill can not be high enough for the player to avoid detection by John Bishop, or this will not work. The quest to kill Westin must have been accepted. When trying to descend the stairs, John Bishop will open dialogue with the player and ask about having killed Westin. He should be told that the player character is "working on it." The dialogue will close, and the player character may descend the stairs. John Bishop will not become hostile. This works multiple times (one may sleep with Mrs. Bishop and Angela Bishop repeatedly with no consequence as long as Westin remains alive).