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Jo may refer to:
- Jo (Fallout 2), the mayor/sheriff of Modoc in Fallout 2.
- Deliver Slag message to Jo in Modoc, a quest in Fallout 2.
- Something strange is happening at the farm northeast of Modoc. Investigate and report back to Jo, a side quest in Fallout 2.
- Jo is suspicious of the Slags. Find out about the dead bodies at the Ghost Farm and find out what happened to Karl, a quest in Fallout 2.
- Jo-Jack Jr., a deceased resident of Goodsprings mentioned in Fallout: New Vegas.
- Jo (Fallout Tactics), a recruit in Fallout Tactics and multiplayer character in Fallout Tactics multiplayer.