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Jesse may refer to:
- Real-life people:
- Jesse Heinig, a developer who worked at Interplay Entertainment as a programmer and additional designer for Fallout and SPECIAL Game System Designer for Fallout 2.
- Jesse Reynolds, a developer who worked at Interplay Entertainment as a programmer of Fallout and Fallout 2.
- Jesse Tucker, a developer who worked at Bethesda Softworks as a level designer for Fallout 3.
- Jesse Farrell, a developer who worked at Obsidian Entertainment as an Area Designer for Fallout: New Vegas.
- Jesse Burch, a voice actor who provided voice for several named and unnamed characters in Fallout: New Vegas including the add-on, Lonesome Road.