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For other characters who appear in the Fallout universe named Jane, see Jane.
Jane's neuro-computational matrix is a copy of a woman that Mr. House had known as "one of Mr. House's girls". Jane makes sure to keep Mr. House "entertained", even after giving up his physical needs.
Should the Courier kill or disable Mr. House, Jane will no longer be present to buy snow globes, and they are stuck in the Courier's inventory. The DLC snow globes will automatically be redeemed upon collection, so Jane is not required to sell them to.
If the Courier upgrades the Securitrons to the Mk II OS, the Courier can ask Jane if she has "done something with her hair". She thanks them, commenting on the new weapons she has available.
When speaking to Jane for the first time after upgrading to the MK II OS, she will comment on how tingly she feels, and how she finds that she now has a missile launcher.
Jane usually comments on the latest quest that the Courier has done for Mr. House when speaking to her: "Mr. House is just pleased as punch you got those securitrons online!" or, "You should have seen Mr. House when he heard you dealt with those Omertas, he was as giddy as a schoolboy!" etc.
Jane is a reference to the 1950s film star Jane Russell.
Jane Russell began her film career on a film with Howard Hughes, the man Robert House is based upon.
In real life, Jane Russell was friends with Marilyn Monroe. A securitron Marilyn was intended to appear in the game, as seen in the concept art, but was cut from the final release.