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Isaac may refer to:
- John Isaac, a research assistant at the West Tek Research Facility mentioned in Fallout.
- Isaac, a Gun Runner in Fallout: New Vegas.
- Bruce Isaac, a fleeing singer hiding in Novac in Fallout: New Vegas.
- Isaac Gant, a Cipher in Van Buren.
- Bring a GECK to Isaac in exchange for his power armor, a quest in Van Buren.
- Isaac dialogue file, dialogue file for Isaac in Van Buren.
- Real-life person: