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Irma is a character mentioned in Fallout 4.
Irma was a woman who lived in the settlement that was established within the ruins of Quincy. She was working on repairs to the defensive walls around the perimeter prior to the Quincy Massacre. Her fate is not detailed, but it can be presumed that she did not survive, as she wasn't with the only known group of survivors that the Sole Survivor meets in the Museum of History.
There is another woman named Irma in Fallout 4 who owns the Memory Den. It is very unlikely - but possible - that these two are one and the same. Evidence to the contrary includes the fact that the Memory Den appears to have been in service some time before the Quincy Massacre.
Irma is mentioned only in Fallout 4.