Outside the hotel on first arrival, 3 Brotherhood of Steel paladins are fighting super mutants. There is no special dialogue or quest activation, the Lone Wanderer can either help them or watch them fight alone against the super mutants.
Inside the hotel, there is a rigged shotgun and a lone paladin sleeping on the bed inside. Setting off the shotgun awakes him or her, but they do not turn hostile. They begin to walk around the rather small hotel.
The accessible area of the hotel is very small. This is due to a collapsed ceiling which blocks off access to anything other than a small entrance room and the hotel lobby.